Difference: DongyanTan (3 vs. 4)

Revision 420 Nov 2009 - Main.KdDerr

META TOPICPARENT	name="TWikiUsers"

Name: dongyan tan
Email: dtan@aecom.yu.edu
Company Name: albert einstein college of medicine
Company URL: http://www.aecom.yu.edu/home/biophysics/
Location: AECOMOffice
Country: USA
Comment:
Project Logbook: CemProposalHernandoJoseSosa11090947LogUser
Publication: Tan D., Rice W.J., Sosa H. Structure of the Kinesin13 Ring Complex. Structure 2008 Nov 12; 16 :1732 1739

Changed:

<
< Toinvestigate the mechanismof kinesin13-inducedmicrotubule depolymerization, we have calculated a three-dimensional (3D)mapof the kinesin13-microtubule ring complex, using cryo-electron microscopy (cryo-EM) and image analysis. An atomic model of the complex was produced by docking the crystal structures of tubulin and a kinesin13 motor domain (MD) into the 3D map. The model reveals a snapshot of the depolymerization mechanism by providing a 3D view of the complex formed between the kinesin13 MD and a curved tubulin protofilament (pf). It suggests that contactsmediated by kinesin13 class-specific residues in the putative microtubule-binding site stabilize intra-dimer tubulin curvature. In addition, a tubulinbinding site on the kinesin13 MD was identified. Mutations at this class-conserved site selectively disrupt the formation of microtubule-associated ring complexes.

>
> To investigate the mechanismof kinesin13-induced microtubule depolymerization, we have calculated a three-dimensional (3D)map of the kinesin13-microtubule ring complex, using cryo-electron microscopy (cryo-EM) and image analysis. An atomic model of the complex was produced by docking the crystal structures of tubulin and a kinesin13 motor domain (MD) into the 3D map. The model reveals a snapshot of the depolymerization mechanism by providing a 3D view of the complex formed between the kinesin13 MD and a curved tubulin protofilament (pf). It suggests that contacts mediated by kinesin13 class-specific residues in the putative microtubule-binding site stabilize intra-dimer tubulin curvature. In addition, a tubulin binding site on the kinesin13 MD was identified. Mutations at this class-conserved site selectively disrupt the formation of microtubule-associated ring complexes.

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