Difference: PaulGottlieb (18 vs. 19)
Revision 1918 Dec 2012 - Main.PaulGottlieb
My Project Logbook-InfluenzaMy Project Logbook-bacteriophagePersonal Preferences (details in TWikiVariables)
| |||||||||||
| Changed: | |||||||||||
| < < | NSF Award Abstract - #9984310 CAREER: Integrated Study and Research in Virology | ||||||||||
| > > | NIH Award Abstract - CAREER: The Molecular Structure of the RNA Polymerase Portal of a Bacteriophage-Reovirus | ||||||||||
| Changed: | |||||||||||
| < < | NSF Org MCB Intial Amendment Date January 14, 2000 Latest Amendment Date December 3, 2002 Award Number 9984310 Award Instrument Continuing grant Program Manager Joanne S. Tornow MCB Division of Molecular and Cellular Biosciences BIO Directorate for Biological Sciences Start Date February 1, 2000 | ||||||||||
| > > | NIH Org NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES Intial Amendment Date May 2010 Latest Amendment Date June 2015 Award Number 1SC1GM092781-01 Award Instrument SCORE SC1 Program Manager Michael Sakalian, Ph.D. Start Date May, 2010 Expires June 2015 (Estimated) Awarded Amount to Date $450,000 | ||||||||||
| Deleted: | |||||||||||
| < < | Expires December 31, 2004 (Estimated) Awarded Amount to Date $391858 | ||||||||||
| Investigator(s) Paul Gottlieb pgottl@med.cuny.edu(Principal Investigator) Sponsor CUNY City College | |||||||||||
| Changed: | |||||||||||
| < < | Convent Ave at 138th St | ||||||||||
| > > | 160 Convent Avenue | ||||||||||
| New York, NY 10031 212/650-5418 | |||||||||||
| Deleted: | |||||||||||
| < < | NSF Program(s) GENE EXPRESSION Field Application(s) 0000099 Other Applications NEC Program Reference Code(s) BIOT,9183,1045 Program Element Code(s) 1154 | ||||||||||
| Abstract | |||||||||||
| Changed: | |||||||||||
| < < | GOTTLIEB: This research will emphasize two scientific projects that demonstrate the fundamentals of virological research for a wide range of students, including those scientifically advanced in High School, undergraduates, and graduate students. "Hands-on" laboratory experience that provides students with the opportunity to develop and test hypotheses and to acquire rigorous scientific methodologies will best reinforce the lessons of the classroom. In this regard, the research includes the following two projects. The three-segmented dsRNA containing Cystoviridae is a non-pathogenic model for the Reoviridae. The goal of the Cystoviridae research is to establish an in vitro RNA replication and packaging system for phi12, one of the newly discovered cystoviruses. Embarking upon a comparative study of these viruses will result in understanding the role of genetic and structural variation on their replicative mechanisms and evolution and answer extant questions in reovirus biology. The aim of the second portion of the project is to test the hypothesis that the alteration of a self antigen by interaction with a viral antigen can render the self antigen immunogenic. The self-antigen to be studied in this case is dsDNA which is proposed to be rendered immunogenic by binding with the EBNA-1 protein of the Epstein-Barr Virus. Integrating teaching with active student research in the molecular biology of viruses, this project centers on developing a virology program for undergraduate, graduate, and advanced high school students. | ||||||||||
| > > | GOTTLIEB: My group has established a comprehensive research program that includes industrial as well as academic subjects. Our virology research focuses upon viral structure, viral assembly, and pathogenicity. Specific projects are defining the replication and assembly mechanisms of Cystoviridae (bacterial reovirus), determining the viral relationships of Epstein Barr Virus (EBV) and Systemic Lupus Erythematosus (SLE), and elaborating upon the structure of influenza vaccine viral particles. We also collaborate with scientists in both the Earth Atmospheric and Space and Physics departments in order to study microbial-environmental interactions that focus on the influence of clay on the assembly of bacterial biofilms. | ||||||||||
| |||||||||||
View topic
| History: r20 < r19 < r18 < r17
| More topic actions...
Copyright © by the contributing authors. All material on this collaboration platform is the property of the contributing authors.
Ideas, requests, problems regarding this intranet, Send feedback
Ideas, requests, problems regarding this intranet, Send feedback