Difference: PhanKuryavyi07 (7 vs. 8)

Revision 818 Apr 2007 - Main.JasperShahn

Changed:

<
<

Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ 'Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter.' 2007 J Am Chem Soc In Press

>
>

Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ 'Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter.' 2007 J Am Chem Soc 129; 4386-4392

The c-kit oncogene is an important target in the treatment of gastrointestinal tumors. A potential approach to inhibition of the expression of this gene involves selective stabilization of G-quadruplex structures that may be induced to form in the c-kit promoter region. Here we report on the structure of an unprecedented intramolecular G-quadruplex formed by a G-rich sequence in the c-kit promoter in K+ solution. The structure represents a new folding topology with several unique features. Most strikingly, an isolated guanine is involved in G-tetrad core formation, despite the presence of four three-guanine tracts. There are four loops: two single-residue double-chain-reversal loops, a two-residue loop, and a five-residue stem-loop, which contain base-pairing alignments. This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit.

View topic | History: r8 < r7 < r6 < r5 | More topic actions...

Copyright © by the contributing authors. All material on this collaboration platform is the property of the contributing authors.
Ideas, requests, problems regarding this intranet, Send feedback