Difference: TemimpsJobs (13 vs. 14)
Revision 1403 May 2012 - Main.DavidStokes
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| > > | Current Job Openings at NYSBC | |||||||
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| > > | Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biology Center | |||||||
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| < < | Jobs Available in the Transcontinental EM Initiative for Membrane Protein Structure | |||||||
| > > | The New York Structural Biology Center (NYSBC) seeks an experienced electron microscopist to join the staff of its Cryo-Electron Microscope Facility (http://cryoem.nysbc.org). The NYSBC is a shared center that supports state-of-the-art research in cryo-EM, NMR, and X-ray. Cryo-EM facilities include four transmission electron microscopes and a dual-beam scanning electron microscope, which support projects involving electron tomography, single particle analysis and electron crystallography of both stained and frozen-hydrated samples. Projects focus on 3D reconstruction of biological assemblies ranging from the atomic structure of membrane proteins, to the subunit organization in macromolecular complexes and the cellular anatomy of developing organisms. Implementation of new technologies is an ongoing interest at NYSBC and, with the dual-beam microscope, NYSBC plans to expand the scale of 3D reconstructions to encompass the characterization of entire cells and their distributions within their native tissue. To assist in these developments, NYSBC seeks a individual with postdoctoral experience in biological electron microscopy and image reconstruction. This individual will carry out experiments in support of collaborative projects with affiliated investigators and will also have opportunities to pursue independent research projects. The individual should be capable of multitasking, should enjoy working with other people, should have a good working knowledge of electron microscopes and a strong research background. Good communication skills are essential. Qualified applicants should send a curriculum vitae and names of three references to David Stokes (stokes@nysbc.org). Salary is commensurate with experience. The position is currently open and applications will be reviewed continuously until the position is filled. | |||||||
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| < < | A number of jobs are available in our new NIH-funded PSI center for Membrane Protein Structure Determination (http://temimps.nysbc.org). Our's is the only PSI center exclusively committed to determination of membrane protein structures using electron microscopy. This will involve development of a number of associated technologies, from high-throughput crystallization screening, automated imaging in the electron microscope, novel approaches for image analysis. Our overall goal is to solve structures over the 5-year period of the grant. The target list includes a wide variety of biologically important proteins, including transporters, pumps, signaling molecules, proteases and adhesion proteins. | |||||||
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| > > | Postdoctoral Position for a Membrane Protein Electron Microscopist | |||||||
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| < < | Electron microscopist at New York University, New York, NY | |||||||
| > > | A postdoctoral position for a highly motivated electron microscopist is available immediately in the laboratory of David Stokes at the New York Structural Biology Center (http://cryoem.nysbc.org) in New York City. The successful applicant will work for the Transcontinental Electron Microscopy Initiative for Membrane Protein Structure (TEMIMPS; http://temimps.nysbc.org). TEMIMPS is funded by the NIH Protein Structure Initiative for development and implementation of high-throughput and high-resolution approaches to structure determination of membrane proteins using electron cryo-microscopy and 2D membrane crystals. TEMIMPS is composed of six research groups with combined expertise in membrane protein production, membrane crystallization, electron microscopy, image processing, and structure determination. Groups at Mt. Sinai School of Medicine, New York University and NYSBC work closely together. The group at Mt. Sinai focuses on production of purified membrane protein targets, whereas the group at NYSBC uses a high-throughput pipeline to screen crystallization conditions. The open position at NYSBC will involve crystallization of membrane proteins 3D reconstruction using methods of electron crystallography. The NYSBC is well equipped for all aspects of this project and hosts superlative facilities for electron cryo-microscopy. Candidates must hold a Ph.D. in Molecular Biology, Biochemistry, Biophysics, Structural Biology or a related field. Strong research experience in membrane protein biochemistry is highly desirable. In addition, the candidate must have strong interpersonal, organizational and communication skills in order to facilitate intimate collaboration with other research groups. Salary will be commensurate with experience. Interested candidates should send a cover letter, curriculum vitae and contact information for three professional referees to Dr. David Stokes at stokes@nysbc.org. | |||||||
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| < < | Postdoctoral position is available immediately for an an electron crystallographer in the laboratory of David Stokes at the Skirball Institute of New York University School of Medicine (http://skirball.med.nyu.edu/~stokes). This position will focus on structure determination of tubular crystals formed by membrane proteins. This work will involve optimization of crystals discovered in the TEMIMPS high-throughput crystallization pipeline, which includes a broad array of novel membrane protein targets (http://temimps.nysbc.org). Structure determination will then involve imaging of frozen-hydrated samples and helical reconstruction using either Fourier Bessel methods or Interative Real Space methods. State-of-the-art cryo-electron microscopes are available both at NYU and at the New York Structural Biology Center for this work. Software for both approaches to helical reconstruction are a development focus for members of the TEMIMPS consortium. Candidate should have a Ph.D. with experience either in electron microscopy or image analysis and an ability to work effectively within the highly collaborative environment of our multi-institutional consortium. To apply, email curriculum vitae and contact information for three professional referees to temimps@nysbc.org or to Dr. David Stokes (stokes@nyu.edu). | |||||||
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