Difference: BtrrInfo (39 vs. 40)

Revision 4022 Jun 2010 - Main.DavidCowburn

 Contents

DRAFT IN PROGRESS Public information concerning application from NYSBC to NIH-NCRR-BTRR program for Dec 2 deadline, 2008

Biomedical Technology Research Resource in Macromolecular Dynamics
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<		PI Arthur Palmer? -- please e-cc dcadmin@nysbc.org on matters concerning this proposal.
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>		PI Main.ArthurPalmer -- please e-cc dcadmin@nysbc.org on matters concerning this proposal.
 

NIH references

Resume

NYSBC has a unique infrastructure and intellectual focus group related to studying dynamic processes of biomolecules, principally by NMR.

An early draft proposal (5 pages) is available.?

Components

Technology Research and Development

Infrastructure

  1. Measurement of intermediate time scale motions
  2. Measurement of fast time scale motions
  3. Provision of protein constructs with appropriate isotopic labeling
    1. Segmental labeling
    2. cell free labeling
    3. chemical biology approaches and non-natural analogs, including PRE tags
  4. Analysis of NMR data for dynamic processes including molecular dynamics simulation
  5. NMR technology areas
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    1. shuttle probe techniques?
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    1. shuttle probe techniques
 
    1. PRE
    2. solid state
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Driving Biomedical Projects (DBP) LetterDraftDBP

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Driving Biomedical Projects (DBP) Main.LetterDraftDBP?

 
  1. Intrinsically unstructured proteins
  2. General mechanisms in enzymology
  3. Membrane proteins
  4. Signal transduction
    1. Kinases/ phophatases
    2. ectodomain signaling
  5. Components of the dynamic interactome
  6. Pleomorphism of nucleic acids
  7. Integrin signaling

Collaboration and Service

The following are involved in likely collaborations with the BTRR, including topics in the "Driving Biomedical Projects" areas . Draft Letter for Collaborators
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  • Aneel Aggarwal?
  • David Cowburn?
  • Mark Girvin?
  • Steve Hubbard?
  • Ann McDermott?
  • Moosa Mohammadi?
  • David Fushman?
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Training

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  1. Access of NIH PI's to related NYSBC courses on line. (See Nmr Education? )
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  1. Access of NIH PI's to related NYSBC courses on line. (See Main.NmrEducation )
 

Dissemination

Administration

  1. Organizational structure
  2. Staff responsibilities
  3. Resource operating procedure
  4. External Advisory Committee
    • TBA
  5. Local Executive Committee
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    • Chair - TBA, Arthur Palmer? PI, Mark Girvin?, David Eliezer?, David Cowburn?
  1. Consultants invited (or pending) Draft Btrr Consultant Letter
    1. Numerical methods Amit Singer?
    2. Database and record keeping Zsolt Zolnai?
    3. NMR data handling Bruce Johnson?
    4. Protein expression methods James Love? Steven Almo?
    5. Crystallography Wayne Hendrickson?
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  1. Consultants invited (or pending) Main.DraftBtrrConsultantLetter?
    1. Numerical methods Main.AmitSinger
    2. Database and record keeping Main.ZsoltZolnai
    3. NMR data handling Main.BruceJohnson
    4. Protein expression methods Main.JamesLove Main.StevenAlmo
    5. Crystallography Main.WayneHendrickson
 

  • Set ALLOWTOPICVIEW =

-- DavidCowburn - 11 Nov 2008

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META TOPICMOVED by="DavidCowburn" date="1277230357" from="Main.BtrrInfo" to="Staffarchive.BtrrInfo"
 
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