DRAFT IN PROGRESS Public information concerning application from NYSBC to NIH-NCRR-BTRR program for Dec 2 deadline, 2008

PI Main.ArthurPalmer -- please e-cc dcadmin@nysbc.org on matters concerning this proposal.

NIH references

• XO2 call for proposals - http://grants.nih.gov/grants/guide/pa-files/PAR-08-260.html
• P41 subsequent application material - http://grants.nih.gov/grants/guide/pa-files/PAR-08-259.html

Resume

An early draft proposal (5 pages) is available.^?

Components

Technology Research and Development

Infrastructure

1. Measurement of intermediate time scale motions
2. Measurement of fast time scale motions
3. Provision of protein constructs with appropriate isotopic labeling
   1. Segmental labeling
   2. cell free labeling
   3. chemical biology approaches and non-natural analogs, including PRE tags
4. Analysis of NMR data for dynamic processes including molecular dynamics simulation
5. NMR technology areas
   1. shuttle probe techniques
   2. PRE
   3. solid state

1. Intrinsically unstructured proteins
2. General mechanisms in enzymology
3. Membrane proteins
4. Signal transduction
   1. Kinases/ phophatases
   2. ectodomain signaling
5. Components of the dynamic interactome
6. Pleomorphism of nucleic acids
7. Integrin signaling

Collaboration and Service

• Main.AneelAggarwal
• Main.DavidCowburn
• Main.MarkGirvin
• Main.SteveHubbard
• Main.AnnMain.McDermott^?
• Main.MoosaMohammadi
• Main.DavidFushman

Training

1. Access of NIH PI's to related NYSBC courses on line. (See Main.NmrEducation )

Dissemination

Administration

1. Organizational structure
2. Staff responsibilities
3. Resource operating procedure
4. External Advisory Committee
   • TBA
5. Local Executive Committee
   • Chair - TBA, Main.ArthurPalmer PI, Main.MarkGirvin, Main.DavidEliezer, Main.DavidCowburn
6. Consultants invited (or pending) DraftBtrrConsultantLetter
   1. Numerical methods Main.AmitSinger
   2. Database and record keeping Main.ZsoltZolnai
   3. NMR data handling Main.BruceJohnson
   4. Protein expression methods Main.JamesLove Main.StevenAlmo
   5. Crystallography Main.WayneHendrickson

• Set ALLOWTOPICVIEW =

-- DavidCowburn - 11 Nov 2008