Palmer/McDermott outline
Additional Reading List:
A. Abragam “Principles of Nuclear Magnetism” Claredon Press (1961).
R. R. Ernst, G Bodenhausen and A Wokaun “Principles of Nuclear Magnetic Resonance in One and Two Dimensions” Oxford Science Publications (1987).
U. Haeberlen“High Resolution NMR in Solids: Selective Averaging” (1976), also published in “Advances in Magnetic Resonance, Supplement 1”.
G. C. K Roberts (Ed.) “NMR of Macromolecules: A practical approach” IRL Press (1993).
K. Wüthrich “NMR of Proteins and Nucleic Acids” Wiley (1986).
P. J. Hore “Nuclear Magnetic Resonance” Oxford Chemistry Primers (1995)
P. J. Hore, J. A. Jones, and S. Wimperis “NMR : The Toolkit” Oxford Chemistry Primers (2000)
Course Outline:
I. Fundamentals of Magnetic Resonance
A. Classical and Quantum Mechanical Description of Magnetic Resonance
B. Product Operator Formalism for Spin 1/2 Nuclei
C. Relaxation and Dynamic Processes
II. Experimental Aspects of NMR Spectroscopy
A. NMR Instrumentation
B. Data Acquisition and Processing
C. One-dimensional NMR spectroscopy
III. Multi-dimensional NMR Spectroscopy
A. NMR in Two, Three and Four Dimensions
B. Coherence and Magnetization Transfer
C. Coherence Selection by Phase Cycling and Field Gradients
IV. Structure Determination by NMR Spectroscopy
A. Techniques for Resonance Assignments
B. Distance Constraints from NOESY Experiments
C. Scalar Coupling Constants and Residual Dipolar Coupling Constants
D. Computational Techniques for Structure Determination and Refinement
V. Investigation of Rate Processes by NMR Spectroscopy
A. Spin Relaxation and Conformational Dynamics
B. Chemical and Conformational Exchange
C. Amide Proton Exchange
VI. Solid State NMR Spectroscopy
A. Tensors and Interactions
B. Magic Angle Spinning
C. Recoupling Methods
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